Chromatinization modulates topoisomerase II processivity

Chromatinization modulates topoisomerase II processivity

Abstract Type IIA topoisomerases are essential DNA processing enzymes that must robustly and reliably relax DNA torsional stress. While cellular processes constantly create varying torsional stress, how this variation impacts type IIA topoisomerase function remains obscure. Using multiple single-mol...

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Bibliographic Details
Main Authors: Jaeyoon Lee, Meiling Wu, James T. Inman, Gundeep Singh, Seong ha Park, Joyce H. Lee, Robert M. Fulbright, Yifeng Hong, Joshua Jeong, James M. Berger, Michelle D. Wang
Format: Article
Language:English
Published: Nature Portfolio 2023-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-42600-z

Internet

https://doi.org/10.1038/s41467-023-42600-z

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