Durable therapeutic gain despite competing mortality in long-term follow-up of a randomized hyperfractionated radiotherapy trial for locally advanced head and neck cancer

Purpose/objective(s): To examine the therapeutic ratio and mortality profile over time in a radiotherapy randomized trial in stage III-IV larynx/pharynx cancer with long-term follow-up. Materials/methods: From 1988 to 1995, 331 cases were randomized to either hyperfractionated (HF) (58 Gy/40 fractio...

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Bibliographic Details
Main Authors: Brian O'Sullivan, Shao Hui Huang, Thomas Keane, Wei Xu, Jie Su, John Waldron, Patrick Gullane, Fei-Fei Liu, Padraig Warde, David Payne, Li Tong, Bernard Cummings
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:Clinical and Translational Radiation Oncology
Online Access:http://www.sciencedirect.com/science/article/pii/S2405630820300033