Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease

Defective Interfering Viral Particle Treatment Reduces Clinical Signs and Protects Hamsters from Lethal Nipah Virus Disease

ABSTRACT Defective interfering particles (DIs) contain a considerably smaller genome than the parental virus but retain replication competency. As DIs can directly or indirectly alter propagation kinetics of the parental virus, they offer a novel approach to antiviral therapy, capitalizing on knowle...

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Bibliographic Details
Main Authors: Stephen R. Welch, Jessica R. Spengler, Jessica R. Harmon, JoAnn D. Coleman-McCray, Florine E. M. Scholte, Sarah C. Genzer, Michael K. Lo, Joel M. Montgomery, Stuart T. Nichol, Christina F. Spiropoulou
Format: Article
Language:English
Published: American Society for Microbiology 2022-04-01
Series:mBio
Subjects:
Nipah virus
defective interfering particles
Syrian hamsters
animal model
henipavirus
treatment
Online Access:https://journals.asm.org/doi/10.1128/mbio.03294-21

Internet

https://journals.asm.org/doi/10.1128/mbio.03294-21

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