Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

Efficacy of Flecainide in Catecholaminergic Polymorphic Ventricular Tachycardia Is Mutation-Independent but Reduced by Calcium Overload

BackgroundThe dual Na+ and cardiac Ca2+-release channel inhibitor, Flecainide (FLEC) is effective in patients with catecholaminergic polymorphic ventricular tachycardia (CPVT), a disease caused by mutations in cardiac Ca2+-release channels (RyR2), calsequestrin (Casq2), or calmodulin. FLEC suppresse...

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Bibliographic Details
Main Authors: Hyun Seok Hwang, Marcelo P. Baldo, Jose Pindado Rodriguez, Michela Faggioni, Bjorn C. Knollmann
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-08-01
Series:Frontiers in Physiology
Subjects:
catecholaminergic polymorphic ventricular tachycardia
flecainide
calcium overload
calsequestrin (Casq2)
cardiac ryanodine receptor (RyR2)
Online Access:https://www.frontiersin.org/article/10.3389/fphys.2019.00992/full

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https://www.frontiersin.org/article/10.3389/fphys.2019.00992/full

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