Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

Generation of a Hutchinson–Gilford progeria syndrome monkey model by base editing

Abstract Many human genetic diseases, including Hutchinson-Gilford progeria syndrome (HGPS), are caused by single point mutations. HGPS is a rare disorder that causes premature aging and is usually caused by a de novo point mutation in the LMNA gene. Base editors (BEs) composed of a cytidine deamina...

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Bibliographic Details
Main Authors: Fang Wang, Weiqi Zhang, Qiaoyan Yang, Yu Kang, Yanling Fan, Jingkuan Wei, Zunpeng Liu, Shaoxing Dai, Hao Li, Zifan Li, Lizhu Xu, Chu Chu, Jing Qu, Chenyang Si, Weizhi Ji, Guang-Hui Liu, Chengzu Long, Yuyu Niu
Format: Article
Language:English
Published: Oxford University Press 2020-07-01
Series:Protein & Cell
Subjects:
base editing
non-human primate
HGPS
Online Access:https://doi.org/10.1007/s13238-020-00740-8

Internet

https://doi.org/10.1007/s13238-020-00740-8

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