Design and synthesis of chiral DOTA-based MRI contrast agents with remarkable relaxivities

Design and synthesis of chiral DOTA-based MRI contrast agents with remarkable relaxivities

Abstract Due to the adverse effects of de-metallation in past concerning FDA-approved gadolinium-based contrast agents (GBCAs), researchers have been focusing on developing safer and more efficient alternatives that could avoid toxicity caused by free gadolinium ions. Herein, two chiral GBCAs, Gd-LS...

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Bibliographic Details
Main Authors: Junhui Zhang, Lixiong Dai, Li He, Abhisek Bhattarai, Chun-Ming Chan, William Chi-Shing Tai, Varut Vardhanabhuti, Ga-Lai Law
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Communications Chemistry
Online Access:https://doi.org/10.1038/s42004-023-01050-w

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https://doi.org/10.1038/s42004-023-01050-w

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