Effects of 1α,25-Dihydroxyvitamin D<sub>3</sub> on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

Effects of 1α,25-Dihydroxyvitamin D<sub>3</sub> on the Pharmacokinetics of Procainamide and Its Metabolite N-Acetylprocainamide, Organic Cation Transporter Substrates, in Rats with PBPK Modeling Approach

In this study, possible changes in the expression of rat organic cationic transporters (rOCTs) and rat multidrug and toxin extrusion proteins (rMATEs) following treatment with 1α,25-dihydroxyvitamin D<sub>3</sub> (1,25(OH)<sub>2</sub>D<sub>3</sub>) were investigat...

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Bibliographic Details
Main Authors: Anusha Balla, Yoo-Seong Jeong, Hyo-Jung Kim, Yun-Jong Lee, Suk-Jae Chung, Yoon-Jee Chae, Han-Joo Maeng
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Pharmaceutics
Subjects:
1α,25-dihydroxyvitamin D<sub>3</sub>
rOCTs
rMATE1
procainamide
N-acetylprocainamide
PBPK modeling
Online Access:https://www.mdpi.com/1999-4923/13/8/1133

Internet

https://www.mdpi.com/1999-4923/13/8/1133

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