Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease

Metabolic reprogramming in inflammatory microglia indicates a potential way of targeting inflammation in Alzheimer's disease

Microglia activation drives the pro-inflammatory activity in the early stages of Alzheimer's disease (AD). However, the mechanistic basis is elusive, and the hypothesis of targeting microglia to prevent AD onset is little explored. Here, we demonstrated that upon LPS exposure, microglia shift t...

Full description

Bibliographic Details
Main Authors: Moris Sangineto, Martina Ciarnelli, Tommaso Cassano, Antonio Radesco, Archana Moola, Vidyasagar Naik Bukke, Antonino Romano, Rosanna Villani, Hina Kanwal, Nazzareno Capitanio, Loren Duda, Carlo Avolio, Gaetano Serviddio
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Redox Biology
Subjects:
Immunometabolism
Alzheimer's disease
Microglia
Dimethyl malonate
Macrophage
Bioenergetics
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231723002471

Internet

http://www.sciencedirect.com/science/article/pii/S2213231723002471

Similar Items