Serine-Threonine Kinases Encoded by Split <italic toggle="yes">hipA</italic> Homologs Inhibit Tryptophanyl-tRNA Synthetase

Serine-Threonine Kinases Encoded by Split <italic toggle="yes">hipA</italic> Homologs Inhibit Tryptophanyl-tRNA Synthetase

ABSTRACT Type II toxin-antitoxin (TA) modules encode a stable toxin that inhibits cell growth and an unstable protein antitoxin that neutralizes the toxin by direct protein-protein contact. hipBA of Escherichia coli strain K-12 codes for HipA, a serine-threonine kinase that phosphorylates and inhibi...

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Bibliographic Details
Main Authors: Stine Vang Nielsen, Kathryn Jane Turnbull, Mohammad Roghanian, Rene Bærentsen, Maja Semanjski, Ditlev E. Brodersen, Boris Macek, Kenn Gerdes
Format: Article
Language:English
Published: American Society for Microbiology 2019-06-01
Series:mBio
Subjects:
persistence
ppGpp
toxin/antitoxin systems
translation
tRNA synthetase
Online Access:https://journals.asm.org/doi/10.1128/mBio.01138-19

Internet

https://journals.asm.org/doi/10.1128/mBio.01138-19

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