Assessment of P2Y12 Inhibition by Clopidogrel in Feline Platelets Using Flow Cytometry Quantification of Vasodilator-Stimulated Phosphoprotein Phosphorylation

Assessment of P2Y12 Inhibition by Clopidogrel in Feline Platelets Using Flow Cytometry Quantification of Vasodilator-Stimulated Phosphoprotein Phosphorylation

The primary objective of this study was to evaluate a novel flow cytometry-based assay of quantifying platelet phosphorylation of vasodilator-stimulated phosphoprotein (P-VASP) in cats that received clopidogrel treatment. Eight healthy cats received 18.75 mg PO q24h of clopidogrel for 7 days. Prior...

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Bibliographic Details
Main Authors: Ronald H. L. Li, Nghi Nguyen, Tommaso Rosati, Karl Jandrey
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Veterinary Science
Subjects:
hypertrophic cardiomyopathy
platelet activation and signaling
light transmission aggregometry
vasodilator stimulated phosphoprotein
cyclic AMP
Online Access:https://www.frontiersin.org/article/10.3389/fvets.2020.00267/full

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https://www.frontiersin.org/article/10.3389/fvets.2020.00267/full

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