Loss of Lipid Carrier ApoE Exacerbates Brain Glial and Inflammatory Responses after Lysosomal GBA1 Inhibition

Tightly regulated and highly adaptive lipid metabolic and transport pathways are critical to maintaining brain cellular lipid homeostasis and responding to lipid and inflammatory stress to preserve brain function and health. Deficits in the lipid handling genes <i>APOE</i> and <i>G...

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Bibliographic Details
Main Authors: Kyle J. Connolly, Juliette Margaria, Erika Di Biase, Oliver Cooper, Penelope J. Hallett, Ole Isacson
Format: Article
Language:English
Published: MDPI AG 2023-11-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/12/21/2564