Homologous acetone carboxylases select Fe(II) or Mn(II) as the catalytic cofactor

Homologous acetone carboxylases select Fe(II) or Mn(II) as the catalytic cofactor

ABSTRACTAcetone carboxylases (ACs) catalyze the metal- and ATP-dependent conversion of acetone and bicarbonate to form acetoacetate. Interestingly, two homologous ACs that have been biochemically characterized have been reported to have different metal complements, implicating different metal depend...

Full description

Bibliographic Details
Main Authors: Krista A. Shisler, William M. Kincannon, Jenna R. Mattice, James Larson, Adam Valaydon-Pillay, Florence Mus, Tamara Flusche, Arnab Kumar Nath, Sebastian A. Stoian, Simone Raugei, Brian Bothner, Jennifer L. DuBois, John W. Peters
Format: Article
Language:English
Published: American Society for Microbiology 2024-02-01
Series:mBio
Subjects:
carboxylase
acetone
manganese
iron
CO2 fixation
Online Access:https://journals.asm.org/doi/10.1128/mbio.02987-23

Internet

https://journals.asm.org/doi/10.1128/mbio.02987-23

Similar Items