SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability.

SMARCAL1 ubiquitylation controls its association with RPA-coated ssDNA and promotes replication fork stability.

Impediments in replication fork progression cause genomic instability, mutagenesis, and severe pathologies. At stalled forks, RPA-coated single-stranded DNA (ssDNA) activates the ATR kinase and directs fork remodeling, 2 key early events of the replication stress response. RFWD3, a recently describe...

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Bibliographic Details
Main Authors: Maïlyn Yates, Isabelle Marois, Edlie St-Hilaire, Daryl A Ronato, Billel Djerir, Chloé Brochu, Théo Morin, Ian Hammond-Martel, Sari Gezzar-Dandashi, Lisa Casimir, Elliot Drobetsky, Laurent Cappadocia, Jean-Yves Masson, Hugo Wurtele, Alexandre Maréchal
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2024-03-01
Series:PLoS Biology
Online Access:https://doi.org/10.1371/journal.pbio.3002552

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https://doi.org/10.1371/journal.pbio.3002552

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