Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia

Upregulation of NKG2D ligands impairs hematopoietic stem cell function in Fanconi anemia

Fanconi anemia (FA) is the most prevalent inherited bone marrow failure (BMF) syndrome. Nevertheless, the pathophysiological mechanisms of BMF in FA have not been fully elucidated. Since FA cells are defective in DNA repair, we hypothesized that FA hematopoietic stem and progenitor cells (HSPCs) mig...

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Bibliographic Details
Main Authors: José A. Casado, Antonio Valeri, Rebeca Sanchez-Domínguez, Paula Vela, Andrea López, Susana Navarro, Omaira Alberquilla, Helmut Hanenberg, Roser Pujol, José-Carlos Segovia, Jordi Minguillón, Jordi Surrallés, Cristina Díaz de Heredia, Julián Sevilla, Paula Rio, Juan A. Bueren
Format: Article
Language:English
Published: American Society for Clinical Investigation 2022-08-01
Series:The Journal of Clinical Investigation
Subjects:
Immunology
Stem cells
Online Access:https://doi.org/10.1172/JCI142842

Internet

https://doi.org/10.1172/JCI142842

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