Response to clozapine in treatment resistant schizophrenia is related to alterations in regional cerebral blood flow

Abstract PET and SPECT studies in treatment-resistant schizophrenia (TRS) have revealed significant alterations in regional cerebral blood flow (CBF) during clozapine treatment, which may vary according to the clinical response. Here, we used the more recent MRI approach of arterial spin labelling (...

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Bibliographic Details
Main Authors: Junyu Sun, Fernando Zelaya, Kyra-Verena Sendt, Grant McQueen, Amy L. Gillespie, John Lally, Oliver D. Howes, Gareth J. Barker, Philip McGuire, James H. MacCabe, Alice Egerton
Format: Article
Language:English
Published: Nature Portfolio 2024-12-01
Series:Schizophrenia
Online Access:https://doi.org/10.1038/s41537-024-00544-3