Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Connexin43 represents an important regulator for Sertoli cell morphology, Sertoli cell nuclear ultrastructure, and Sertoli cell maturation

Abstract The Sertoli cell (SC)-specific knockout (KO) of connexin43 (Cx43) was shown to be an effector of multiple histological changes in tubular morphology, resulting in germ cell loss through to a Sertoli-cell-only (SCO) phenotype and vacuolated seminiferous tubules containing SC-clusters. Our pr...

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Bibliographic Details
Main Authors: Sarah Staggenborg, Rüdiger Koch, Kristina Rode, Hanna Hüneke, Louiza Tiedje, Gudrun Wirth, Marion Langeheine, Ines Blume, Kerstin Rohn, Christoph Wrede, Christiane Pfarrer, Ralph Brehm
Format: Article
Language:English
Published: Nature Portfolio 2022-07-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-16919-4

Internet

https://doi.org/10.1038/s41598-022-16919-4

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