Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice

Characterization of a commonly used mouse model of SMA reveals increased seizure susceptibility and heightened fear response in FVB/N mice

The SMN2 transgenic mouse, Tg(SMN2)89Ahmb, has emerged as the most widely used in spinal muscular atrophy (SMA) research. Here we clone the genomic integration site of the transgene and demonstrate it to be in intron 4 of the metabotropic glutamate receptor 7 (mGluR7) gene. We found that the integra...

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Bibliographic Details
Main Authors: Rocky G. Gogliotti, Cathleen Lutz, Michael Jorgensen, Kimberly Huebsch, Sookyong Koh, Christine J. DiDonato
Format: Article
Language:English
Published: Elsevier 2011-07-01
Series:Neurobiology of Disease
Subjects:
Mouse
Spinal muscular atrophy
SMA
Metabotropic glutamate receptor 7
Seizure
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996111000738

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http://www.sciencedirect.com/science/article/pii/S0969996111000738

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