An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), wh...

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Bibliographic Details
Main Authors: Zhimin Wu, Jun Sun, Zhi Liao, Jia Qiao, Chuan Chen, Cong Ling, Hui Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Neuroscience
Subjects:
long-chain acyl-coenzyme A synthetases (ACSLs)
fatty acid (FA) metabolism
ferroptosis
nervous system diseases
targeted therapy
Online Access:https://www.frontiersin.org/articles/10.3389/fnins.2022.1030512/full

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https://www.frontiersin.org/articles/10.3389/fnins.2022.1030512/full

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