An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

An update on the therapeutic implications of long-chain acyl-coenzyme A synthetases in nervous system diseases

Long-chain acyl-coenzyme A synthetases (ACSLs) are a family of CoA synthetases that activate fatty acid (FA) with chain lengths of 12–20 carbon atoms by forming the acyl-AMP derivative in an isozyme-specific manner. This family mainly includes five members (ACSL1, ACSL3, ACSL4, ACSL5, and ACSL6), wh...

Full description

Bibliographic Details
Main Authors:	Zhimin Wu, Jun Sun, Zhi Liao, Jia Qiao, Chuan Chen, Cong Ling, Hui Wang
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2022-11-01
Series:	Frontiers in Neuroscience
Subjects:	long-chain acyl-coenzyme A synthetases (ACSLs) fatty acid (FA) metabolism ferroptosis nervous system diseases targeted therapy
Online Access:	https://www.frontiersin.org/articles/10.3389/fnins.2022.1030512/full

Similar Items

The Roles of Coenzyme A Binding Pocket Residues in Short and Medium Chain Acyl-CoA Synthetases
by: Yu Meng, et al.
Published: (2023-07-01)

Gene deletion of long-chain acyl-CoA synthetase 4 attenuates xenobiotic chemical-induced lung injury via the suppression of lipid peroxidation
by: Yuki Tomitsuka, et al.
Published: (2023-10-01)

Genome-wide analysis of the acyl-coenzyme A synthetase family and their association with the formation of goat milk flavour
by: Fuhong Zhang, et al.
Published: (2022-09-01)

A broad inhibitor of acyl-acyl carrier protein synthetases
by: Magdalena Todorinova, et al.
Published: (2023-09-01)

Acyl‐CoA synthetase expression in human skeletal muscle is reduced in obesity and insulin resistance
by: Margarete Poppelreuther, et al.
Published: (2023-09-01)

A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation
by: Gajanan S Patil, et al.
Published: (2021-09-01)

Characteristics of long‐chain acyl‐CoA synthetases in metabolism and cancer
by: Linlin Zhang, et al.
Published: (2023-06-01)

ACSL4-Mediated Ferroptosis and Its Potential Role in Central Nervous System Diseases and Injuries
by: Bowen Jia, et al.
Published: (2023-06-01)

Outlook: Membrane junctions enable the metabolic trapping of fatty acids by intracellular acyl-CoA synthetases
by: Joachim eFuellekrug, et al.
Published: (2012-10-01)

ACSL3 and ACSL4, Distinct Roles in Ferroptosis and Cancers
by: Yufei Yang, et al.
Published: (2022-11-01)

Enhanced productivity of extracellular free fatty acids by gene disruptions of acyl-ACP synthetase and S-layer protein in Synechocystis sp. PCC 6803
by: Kamonchanock Eungrasamee, et al.
Published: (2022-09-01)

Genome-Wide Identification and Expression Profiling Analysis of the Long-Chain Acyl-CoA Synthetases Reveal Their Potential Roles in Wheat Male Fertility
by: Yongjie Liu, et al.
Published: (2022-10-01)

Expression of acyl-CoA synthetase medium-chain 3 is associated with obesity in melanoma patients and correlates with androgen receptor
by: Yuan Zheng, et al.
Published: (2023-01-01)

Inhibitory Investigations of Acyl-CoA Derivatives against Human Lipoxygenase Isozymes
by: Michelle Tran, et al.
Published: (2023-06-01)

The acyl-CoA synthetase TgACS1 allows neutral lipid metabolism and extracellular motility in Toxoplasma gondii through relocation via its peroxisomal targeting sequence (PTS) under low nutrient conditions
by: Sarah Charital, et al.
Published: (2024-04-01)

Acyl-coenzyme A binding protein MoAcb1 regulates conidiation and pathogenicity in Magnaporthe oryzae
by: Na Cao, et al.
Published: (2023-04-01)

Heat shock protein 27 deficiency promotes ferrous ion absorption and enhances acyl-Coenzyme A synthetase long-chain family member 4 stability to promote glioblastoma cell ferroptosis
by: Kai Zhang, et al.
Published: (2023-01-01)

Enhancement of E. coli acyl-CoA synthetase FadD activity on medium chain fatty acids
by: Tyler J. Ford, et al.
Published: (2015-06-01)

Structural snapshots for the conformation-dependent catalysis by human medium-chain acyl-coenzyme A synthetase ACSM2A
by: Kochan, G, et al.
Published: (2009)

Molecular Cloning, Characterization, and Expression Regulation of Acyl-CoA Synthetase 6 Gene and Promoter in Common Carp <i>Cyprinus carpio</i>
by: Dizhi Xie, et al.
Published: (2020-07-01)

Genome-Wide Analysis and Functional Characterization of <i>LACS</i> Gene Family Associated with Lipid Synthesis in Cotton (<i>Gossypium</i> spp.)
by: Yike Zhong, et al.
Published: (2023-05-01)

Optimization of Milbemycin Component Ratio by Coordinating Acyl-Coenzyme A Supply Pathways in <i>Streptomyces bingchenggensis</i>
by: Xue Yang, et al.
Published: (2023-06-01)

Effects of Long-Chain Fatty Acyl-CoA Synthetase 1 on Diglyceride Synthesis and Arachidonic Acid Metabolism in Sheep Adipocytes
by: Yang Cao, et al.
Published: (2020-03-01)

Lysophosphatidylcholine inhibits lung cancer cell proliferation by regulating fatty acid metabolism enzyme long‐chain acyl‐coenzyme A synthase 5
by: Linlin Zhang, et al.
Published: (2023-01-01)

Inhibition of CARM1‐Mediated Methylation of ACSL4 Promotes Ferroptosis in Colorectal Cancer
by: Shengjie Feng, et al.
Published: (2023-12-01)

The ACSL4 Network Regulates Cell Death and Autophagy in Diseases
by: Fangquan Chen, et al.
Published: (2023-06-01)

Specificity protein 1-mediated ACSL4 transcription promoted the osteoarthritis progression through suppressing the ferroptosis of chondrocytes
by: Wen He, et al.
Published: (2023-03-01)

ACSL3 regulates lipid droplet biogenesis and ferroptosis sensitivity in clear cell renal cell carcinoma
by: Timothy D. Klasson, et al.
Published: (2022-10-01)

Acyl–Acyl Carrier Protein Desaturases and Plant Biotic Interactions
by: Sami Kazaz, et al.
Published: (2021-03-01)

Glycogen storage disease type Ia misdiagnosed as multiple acyl-coenzyme A dehydrogenase deficiency by mass spectrometry
by: Juan Du, et al.
Published: (2022-11-01)

LPS Induces GM-CSF Production by Breast Cancer MDA-MB-231 Cells via Long-Chain Acyl-CoA Synthetase 1
by: Fatema Al-Rashed, et al.
Published: (2020-10-01)

Short-chain fatty acids activate acetyltransferase p300
by: Sydney P Thomas, et al.
Published: (2021-10-01)

Coenzyme Q10 Phytosome Formulation Improves CoQ10 Bioavailability and Mitochondrial Functionality in Cultured Cells
by: Nicola Rizzardi, et al.
Published: (2021-06-01)

Introduction to enzyme and coenzyme chemistry /
by: 287392 Bugg, Tim
Published: (2012)

Introduction to enzyme and coenzyme chemistry /
by: 287392 Bugg, Tim
Published: (2004)

Vitamin D Attenuates Ulcerative Colitis by Inhibiting ACSL4-Mediated Ferroptosis
by: Shuo Gao, et al.
Published: (2023-11-01)

Thrombin induces ferroptosis in triple-negative breast cancer through the cPLA2α/ACSL4 signaling pathway
by: Shuo Xu, et al.
Published: (2024-01-01)

Relationship Between ACSL4-Mediated Ferroptosis and Chronic Obstructive Pulmonary Disease
by: Wang Y, et al.
Published: (2023-02-01)

Multiple Acyl-Coenzyme A Dehydrogenase Deficiency Leading to Severe Metabolic Acidosis in a Young Adult
by: Karthik Subbu, MD, et al.
Published: (2023-01-01)

Genome‑wide analysis of the maize LACS gene family and functional characterization of the ZmLACS9 responses to heat stress
by: XiuChen Wang, et al.
Published: (2023-12-01)