In-vivo time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats

In-vivo time course of organ uptake and blood-brain-barrier permeation of poly(L-lactide) and poly(perfluorodecyl acrylate) nanoparticles with different surface properties in unharmed and brain-traumatized rats

BackgroundTraumatic brain injury (TBI) has a dramatic impact on mortality and quality of life and the development of effective treatment strategies is of great socio-economic relevance. A growing interest exists in using polymeric nanoparticles (NPs) as carriers across the blood-brain barrier (BBB)...

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Bibliographic Details
Main Authors: Patrick Bechinger, Lucas Serrano Sponton, Verena Grützner, Anna Musyanovych, Daniel Jussen, Harald Krenzlin, Daniela Eldahaby, Nicole Riede, Oliver Kempski, Florian Ringel, Beat Alessandri
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Neurology
Subjects:
nanoparticles
controlled cortical impact
blood–brain barrier
traumatic brain injury
inflammation
Online Access:https://www.frontiersin.org/articles/10.3389/fneur.2023.994877/full

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https://www.frontiersin.org/articles/10.3389/fneur.2023.994877/full

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