The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives
Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena. Studies have highlighted its importance regarding intracellular signaling cascades as well as membrane-bound S1P receptor (S1PR) engagement in va...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/9/6/1515 |
| _version_ | 1797564519211335680 |
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| author | Alexandra Lucaciu Robert Brunkhorst Josef M. Pfeilschifter Waltraud Pfeilschifter Julien Subburayalu |
| author_facet | Alexandra Lucaciu Robert Brunkhorst Josef M. Pfeilschifter Waltraud Pfeilschifter Julien Subburayalu |
| author_sort | Alexandra Lucaciu |
| collection | DOAJ |
| description | Sphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena. Studies have highlighted its importance regarding intracellular signaling cascades as well as membrane-bound S1P receptor (S1PR) engagement in various clinical conditions. In neurological disorders, the S1P–S1PR axis is acknowledged in neurodegenerative, neuroinflammatory, and cerebrovascular disorders. Modulators of S1P signaling have enabled an immense insight into fundamental pathological pathways, which were pivotal in identifying and improving the treatment of human diseases. However, its intricate molecular signaling pathways initiated upon receptor ligation are still poorly elucidated. In this review, the authors highlight the current evidence for S1P signaling in neurodegenerative and neuroinflammatory disorders as well as stroke and present an array of drugs targeting the S1P signaling pathway, which are being tested in clinical trials. Further insights on how the S1P–S1PR axis orchestrates disease initiation, progression, and recovery may hold a remarkable potential regarding therapeutic options in these neurological disorders. |
| first_indexed | 2024-03-10T18:58:19Z |
| format | Article |
| id | doaj.art-7aa4b029dd524aa196bc02a32fab10da |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T18:58:19Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-7aa4b029dd524aa196bc02a32fab10da2023-11-20T04:35:10ZengMDPI AGCells2073-44092020-06-0196151510.3390/cells9061515The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic PerspectivesAlexandra Lucaciu0Robert Brunkhorst1Josef M. Pfeilschifter2Waltraud Pfeilschifter3Julien Subburayalu4Department of Neurology, University Hospital Frankfurt, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurology, RWTH Aachen University, 52074 Aachen, GermanyInstitute of General Pharmacology and Toxicology, Pharmazentrum Frankfurt, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Neurology, University Hospital Frankfurt, Goethe University Frankfurt, 60528 Frankfurt am Main, GermanyDepartment of Medicine, Addenbrooke’s Hospital, University of Cambridge, Cambridge CB2 0QQ, UKSphingosine 1-phosphate (S1P), derived from membrane sphingolipids, is a pleiotropic bioactive lipid mediator capable of evoking complex immune phenomena. Studies have highlighted its importance regarding intracellular signaling cascades as well as membrane-bound S1P receptor (S1PR) engagement in various clinical conditions. In neurological disorders, the S1P–S1PR axis is acknowledged in neurodegenerative, neuroinflammatory, and cerebrovascular disorders. Modulators of S1P signaling have enabled an immense insight into fundamental pathological pathways, which were pivotal in identifying and improving the treatment of human diseases. However, its intricate molecular signaling pathways initiated upon receptor ligation are still poorly elucidated. In this review, the authors highlight the current evidence for S1P signaling in neurodegenerative and neuroinflammatory disorders as well as stroke and present an array of drugs targeting the S1P signaling pathway, which are being tested in clinical trials. Further insights on how the S1P–S1PR axis orchestrates disease initiation, progression, and recovery may hold a remarkable potential regarding therapeutic options in these neurological disorders.https://www.mdpi.com/2073-4409/9/6/1515sphingosine 1-phoshatesphingosine 1-phosphate receptorS1P<sub>1–5</sub>sphingosine 1-phosphate metabolismsphingosine 1-phosphate antagonistst/inhibitorssphingosine 1-phosphate signaling |
| spellingShingle | Alexandra Lucaciu Robert Brunkhorst Josef M. Pfeilschifter Waltraud Pfeilschifter Julien Subburayalu The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives Cells sphingosine 1-phoshate sphingosine 1-phosphate receptor S1P<sub>1–5</sub> sphingosine 1-phosphate metabolism sphingosine 1-phosphate antagonistst/inhibitors sphingosine 1-phosphate signaling |
| title | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives |
| title_full | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives |
| title_fullStr | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives |
| title_full_unstemmed | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives |
| title_short | The S1P–S1PR Axis in Neurological Disorders—Insights into Current and Future Therapeutic Perspectives |
| title_sort | s1p s1pr axis in neurological disorders insights into current and future therapeutic perspectives |
| topic | sphingosine 1-phoshate sphingosine 1-phosphate receptor S1P<sub>1–5</sub> sphingosine 1-phosphate metabolism sphingosine 1-phosphate antagonistst/inhibitors sphingosine 1-phosphate signaling |
| url | https://www.mdpi.com/2073-4409/9/6/1515 |
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