Novel combinatorial therapy of oncolytic adenovirus AdV5/3-D24-ICOSL-CD40L with anti PD-1 exhibits enhanced anti-cancer efficacy through promotion of intratumoral T-cell infiltration and modulation of tumour microenvironment in mesothelioma mouse model

Novel combinatorial therapy of oncolytic adenovirus AdV5/3-D24-ICOSL-CD40L with anti PD-1 exhibits enhanced anti-cancer efficacy through promotion of intratumoral T-cell infiltration and modulation of tumour microenvironment in mesothelioma mouse model

IntroductionMalignant mesothelioma is a rare and aggressive form of cancer. Despite improvements in cancer treatment, there are still no curative treatment modalities for advanced stage of the malignancy. The aim of this study was to evaluate the anti-tumor efficacy of a novel combinatorial therapy...

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Main Authors: Mariangela Garofalo, Magdalena Wieczorek, Ines Anders, Monika Staniszewska, Michal Lazniewski, Marta Prygiel, Aleksandra Anna Zasada, Teresa Szczepińska, Dariusz Plewczynski, Stefano Salmaso, Paolo Caliceti, Vincenzo Cerullo, Ramon Alemany, Beate Rinner, Katarzyna Pancer, Lukasz Kuryk
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Oncology
Subjects:
immune checkpoint inhibitors
immunotherapy
oncolytic adenovirus
mesothelioma
anti PD-1
TILs
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2023.1259314/full

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https://www.frontiersin.org/articles/10.3389/fonc.2023.1259314/full

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