Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Middle East respiratory syndrome coronavirus M protein suppresses type I interferon expression through the inhibition of TBK1-dependent phosphorylation of IRF3

Middle East respiratory syndrome coronavirus (MERS-CoV) infection has claimed hundreds of lives and has become a global threat since its emergence in Saudi Arabia in 2012. The ability of MERS-CoV to evade the host innate antiviral response may contribute to its severe pathogenesis. Many MERS-CoV-enc...

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Bibliographic Details
Main Authors: Pak-Yin Lui, Lok-Yin Roy Wong, Cheuk-Lai Fung, Kam-Leung Siu, Man-Lung Yeung, Kit-San Yuen, Chi-Ping Chan, Patrick Chiu-Yat Woo, Kwok-Yung Yuen, Dong-Yan Jin
Format: Article
Language:English
Published: Taylor & Francis Group 2016-01-01
Series:Emerging Microbes and Infections
Subjects:
innate antiviral response
IRF3 activation
MERS coronavirus
RIG-I-like receptors
type I interferons
Online Access:https://www.tandfonline.com/doi/10.1038/emi.2016.33

Internet

https://www.tandfonline.com/doi/10.1038/emi.2016.33

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