Trap and ambush therapy using sequential primary and tumor escape-selective oncolytic viruses

Trap and ambush therapy using sequential primary and tumor escape-selective oncolytic viruses

In multiple models of oncolytic virotherapy, it is common to see an early anti-tumor response followed by recurrence. We have previously shown that frontline treatment with oncolytic VSV-IFN-β induces APOBEC proteins, promoting the selection of specific mutations that allow tumor escape. Of these mu...

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Bibliographic Details
Main Authors: Mason J. Webb, Timothy Kottke, Benjamin L. Kendall, Jack Swanson, Chisom Uzendu, Jason Tonne, Jill Thompson, Muriel Metko, Madelyn Moore, Mitesh Borad, Lewis Roberts, Rosa M. Diaz, Michael Olin, Antonella Borgatti, Richard Vile
Format: Article
Language:English
Published: Elsevier 2023-06-01
Series:Molecular Therapy: Oncolytics
Subjects:
oncolytic virotherapy
immunotherapy
CSDE1
vesicular stomatitis virus
VSV
melanoma
Online Access:http://www.sciencedirect.com/science/article/pii/S2372770523000396

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http://www.sciencedirect.com/science/article/pii/S2372770523000396

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