Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent.

Tumour cell generation of inducible regulatory T-cells in multiple myeloma is contact-dependent and antigen-presenting cell-independent.

Regulatory T-cells (T(Reg) cells) are increased in patients with multiple myeloma (MM). We investigated whether MM cells could generate and/or expand T(Reg) cells as a method of immuno-surveillance avoidance. In an in vitro model, CD4(+)CD25(-)FoxP3(-) T-cells co-cultured with malignant plasma cells...

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Bibliographic Details
Main Authors: Sylvia Feyler, Gina B Scott, Christopher Parrish, Sarah Jarmin, Paul Evans, Mike Short, Katherine McKinley, Peter J Selby, Gordon Cook
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3362588?pdf=render

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http://europepmc.org/articles/PMC3362588?pdf=render

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