May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?

May we routinely spare hippocampal region in primary central nervous system lymphoma during whole brain radiotherapy?

Abstract Purpose One of the main limiting factors of whole-brain radiation therapy (WBRT) for primary central nervous system lymphoma (PCNSL) is the impairment of neurocognitive functions (NCFs), which is mainly caused by radiation-induced injury to the hippocampus. With a view to preventing NCF imp...

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Bibliographic Details
Main Authors: Ciro Mazzarella, Silvia Chiesa, Lucrezia Toppi, Stefan Hohaus, Simona Gaudino, Francesco D’Alo, Nicola Dinapoli, Resta Davide, Tiziano Zinicola, Serena Bracci, Antonella Martino, Francesco Beghella Bartoli, Elisabetta Lepre, Roberta Bertolini, Silvia Mariani, Cesare Colosimo, Vincenzo Frascino, Gian Carlo Mattiucci, Maria Antonietta Gambacorta, Vincenzo Valentini, Mario Balducci
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Radiation Oncology
Subjects:
PCNSL
Hippocampal sparing
WBRT
IMRT
Neuro-toxicity
Personalized treatment
Online Access:https://doi.org/10.1186/s13014-023-02251-2

Internet

https://doi.org/10.1186/s13014-023-02251-2

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