The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis
Introduction To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). Material and methods SNP genotyping was performed using genomic DNA...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Termedia Publishing House
2023-05-01
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| Series: | Archives of Medical Science |
| Subjects: | |
| Online Access: | https://www.archivesofmedicalscience.com/The-impact-of-single-nucleotide-polymorphisms-in-MTHFR-and-MTRR-genes-on-disease,163259,0,2.html |
| _version_ | 1827620450176335872 |
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| author | Justyna Roszkiewicz Dominika Michałek Aleksandra Ryk Bartosz Szmyd Elzbieta Smolewska |
| author_facet | Justyna Roszkiewicz Dominika Michałek Aleksandra Ryk Bartosz Szmyd Elzbieta Smolewska |
| author_sort | Justyna Roszkiewicz |
| collection | DOAJ |
| description | Introduction
To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA).
Material and methods
SNP genotyping was performed using genomic DNA isolated from peripheral blood samples.
Results
Patients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis.
Conclusions
MTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis. |
| first_indexed | 2024-03-09T10:47:28Z |
| format | Article |
| id | doaj.art-7abb3f0553854f37b3ef0f3ff7917c08 |
| institution | Directory Open Access Journal |
| issn | 1734-1922 1896-9151 |
| language | English |
| last_indexed | 2024-03-09T10:47:28Z |
| publishDate | 2023-05-01 |
| publisher | Termedia Publishing House |
| record_format | Article |
| series | Archives of Medical Science |
| spelling | doaj.art-7abb3f0553854f37b3ef0f3ff7917c082023-12-01T09:51:47ZengTermedia Publishing HouseArchives of Medical Science1734-19221896-91512023-05-0119381081310.5114/aoms/163259163259The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritisJustyna Roszkiewicz0https://orcid.org/0000-0003-1487-7156Dominika Michałek1https://orcid.org/0000-0002-0634-0319Aleksandra Ryk2https://orcid.org/0000-0002-6146-2888Bartosz Szmyd3https://orcid.org/0000-0002-4051-0887Elzbieta Smolewska4https://orcid.org/0000-0002-8421-0448Department of Pediatric Cardiology and Rheumatology, Medical University of Lodz, PolandDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, PolandDepartment of Biostatistics and Translational Medicine, Medical University of Lodz, PolandDepartment of Pediatrics, Oncology and Hematology, Medical University of Lodz, Lodz, PolandDepartment of Pediatric Cardiology and Rheumatology, Medical University of Lodz, PolandIntroduction To determine the impact of single nucleotide polymorphisms (SNPs) in MTHFR and MTRR genes on disease activity and the presence of MTX therapy adverse events in Polish children with juvenile idiopathic arthritis (JIA). Material and methods SNP genotyping was performed using genomic DNA isolated from peripheral blood samples. Results Patients with MTHFR rs1801133 CT/TT variant had higher values of inflammatory markers, number of joints with active arthritis, and JADAS-71 value at the baseline of MTX treatment. Children with MTRR rs1801394 AG/AA variant presented higher inflammatory marker values at JIA diagnosis. Conclusions MTHFR rs1801133 and MTRR rs1801394 polymorphisms are associated with higher disease activity at the moment of JIA diagnosis.https://www.archivesofmedicalscience.com/The-impact-of-single-nucleotide-polymorphisms-in-MTHFR-and-MTRR-genes-on-disease,163259,0,2.htmlmethotrexatepharmacogenomicssingle nucleotide polymorphismjuvenile idiopathic arthritis |
| spellingShingle | Justyna Roszkiewicz Dominika Michałek Aleksandra Ryk Bartosz Szmyd Elzbieta Smolewska The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis Archives of Medical Science methotrexate pharmacogenomics single nucleotide polymorphism juvenile idiopathic arthritis |
| title | The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| title_full | The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| title_fullStr | The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| title_full_unstemmed | The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| title_short | The impact of single nucleotide polymorphisms in MTHFR and MTRR genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| title_sort | impact of single nucleotide polymorphisms in mthfr and mtrr genes on disease activity and the presence of methotrexate treatment side effects in children with juvenile idiopathic arthritis |
| topic | methotrexate pharmacogenomics single nucleotide polymorphism juvenile idiopathic arthritis |
| url | https://www.archivesofmedicalscience.com/The-impact-of-single-nucleotide-polymorphisms-in-MTHFR-and-MTRR-genes-on-disease,163259,0,2.html |
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