Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F<sub>1</sub>F<sub>O</sub>-ATPase and Mitochondrial Permeability Transition Pore Formation

Novel Regioselective Synthesis of 1,3,4,5-Tetrasubstituted Pyrazoles and Biochemical Valuation on F<sub>1</sub>F<sub>O</sub>-ATPase and Mitochondrial Permeability Transition Pore Formation

An efficient, eco-compatible, and very cheap method for the construction of fully substituted pyrazoles (Pzs) via eliminative nitrilimine-alkene 1,3-dipolar cycloaddition (ENAC) reaction was developed in excellent yield and high regioselectivity. Enaminones and nitrilimines generated in situ were se...

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Bibliographic Details
Main Authors: Vincenzo Algieri, Cristina Algieri, Paola Costanzo, Giulia Fiorani, Antonio Jiritano, Fabrizio Olivito, Matteo Antonio Tallarida, Fabiana Trombetti, Loredana Maiuolo, Antonio De Nino, Salvatore Nesci
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Pharmaceutics
Subjects:
pyrazoles
1,3-dipolar cycloaddition
hydrazonyl chlorides
mitochondrial permeability transition pore
F<sub>1</sub>F<sub>O</sub>-ATPase
Online Access:https://www.mdpi.com/1999-4923/15/2/498

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https://www.mdpi.com/1999-4923/15/2/498

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