DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.

DNA variation in the SNAP25 gene confers risk to ADHD and is associated with reduced expression in prefrontal cortex.

The Coloboma mouse carries a ∼2 cM deletion encompassing the SNAP25 gene and has a hyperactive phenotype similar to that of ADHD. Such mice are 3 fold more active compared to their control littermates. Genetic association studies support a role for allelic variants of the human SNAP25 gene in predis...

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Bibliographic Details
Main Authors: Ziarih Hawi, Natasha Matthews, Joseph Wagner, Robyn H Wallace, Tim J Butler, Alasdair Vance, Lindsey Kent, Michael Gill, Mark A Bellgrove
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3625226?pdf=render

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http://europepmc.org/articles/PMC3625226?pdf=render

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