Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing

Early chromosome condensation by XIST builds A-repeat RNA density that facilitates gene silencing

Summary: XIST RNA triggers chromosome-wide gene silencing and condenses an active chromosome into a Barr body. Here, we use inducible human XIST to examine early steps in the process, showing that XIST modifies cytoarchitecture before widespread gene silencing. In just 2–4 h, barely visible transcri...

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Bibliographic Details
Main Authors: Melvys Valledor, Meg Byron, Brett Dumas, Dawn M. Carone, Lisa L. Hall, Jeanne B. Lawrence
Format: Article
Language:English
Published: Elsevier 2023-07-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Stem cell research
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723006976

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http://www.sciencedirect.com/science/article/pii/S2211124723006976

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