Neutralizing antibodies targeting a novel epitope on envelope protein exhibited broad protection against flavivirus without risk of disease enhancement

Neutralizing antibodies targeting a novel epitope on envelope protein exhibited broad protection against flavivirus without risk of disease enhancement

Abstract Background Flavivirus causes many serious public health problems worldwide. However, licensed DENV vaccine has restrictions on its use, and there is currently no approved ZIKV vaccine. Development of a potent and safe flavivirus vaccine is urgently needed. As a previous study revealed the e...

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Bibliographic Details
Main Authors: Li-Chen Yen, Hsin-Wei Chen, Chia-Lo Ho, Chang-Chi Lin, Yi-Ling Lin, Qiao-Wen Yang, Kuo-Chou Chiu, Shu-Pei Lien, Ren-Jye Lin, Ching-Len Liao
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Journal of Biomedical Science
Subjects:
Japanese encephalitis virus
Dengue virus
Zika virus
Flavivirus vaccine
Neutralizing epitope
Envelop protein domain II
Online Access:https://doi.org/10.1186/s12929-023-00938-y

Internet

https://doi.org/10.1186/s12929-023-00938-y

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