Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain

Broadly applicable TCR-based therapy for multiple myeloma targeting the immunoglobulin J chain

Abstract Background The immunoglobulin J chain (Jchain) is highly expressed in the majority of multiple myeloma (MM), and Jchain-derived peptides presented in HLA molecules may be suitable antigens for T-cell therapy of MM. Methods Using immunopeptidomics, we identified Jchain-derived epitopes prese...

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Bibliographic Details
Main Authors: Miranda H. Meeuwsen, Anne K. Wouters, Tassilo L. A. Wachsmann, Renate S. Hagedoorn, Michel G. D. Kester, Dennis F. G. Remst, Dirk M. van der Steen, Arnoud H. de Ru, Els P. van Hees, Martijn Kremer, Marieke Griffioen, Peter A. van Veelen, J. H. Frederik Falkenburg, Mirjam H. M. Heemskerk
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Hematology & Oncology
Online Access:https://doi.org/10.1186/s13045-023-01408-6

Internet

https://doi.org/10.1186/s13045-023-01408-6

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