Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure
Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a series of thermogenic redox reactions, electrons are shuttled through the ETS to oxygen as the final electron acceptor. This...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-12-01
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| Series: | Frontiers in Molecular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmmed.2023.1305960/full |
| _version_ | 1797403228297494528 |
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| author | Marten Szibor Marten Szibor Marie Mühlon Torsten Doenst Jaakko L. O. Pohjoismäki |
| author_facet | Marten Szibor Marten Szibor Marie Mühlon Torsten Doenst Jaakko L. O. Pohjoismäki |
| author_sort | Marten Szibor |
| collection | DOAJ |
| description | Cardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a series of thermogenic redox reactions, electrons are shuttled through the ETS to oxygen as the final electron acceptor. This electron transfer is coupled to proton translocation across the inner mitochondrial membrane, which itself is the main driving force for ATP production. Oxygen availability is thus a prerequisite for ATP production and consequently contractility. Notably, cardiomyocytes are exceptionally large cells and densely packed with contractile structures, which constrains intracellular oxygen distribution. Moreover, oxygen must pass through layers of actively respiring mitochondria to reach the ones located in the innermost contractile compartment. Indeed, uneven oxygen distribution was observed in cardiomyocytes, suggesting that local ATP supply may also vary according to oxygen availability. Here, we discuss how spatial adjustment of bioenergetics to intracellular oxygen fluctuations may underlie cardiac contractile adaptation and how this adaptation may pose a risk for the development of contractile failure. |
| first_indexed | 2024-03-09T02:35:31Z |
| format | Article |
| id | doaj.art-7ad86c2b131942e48672a3c151b65ca8 |
| institution | Directory Open Access Journal |
| issn | 2674-0095 |
| language | English |
| last_indexed | 2024-03-09T02:35:31Z |
| publishDate | 2023-12-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Molecular Medicine |
| spelling | doaj.art-7ad86c2b131942e48672a3c151b65ca82023-12-06T08:37:01ZengFrontiers Media S.A.Frontiers in Molecular Medicine2674-00952023-12-01310.3389/fmmed.2023.13059601305960Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failureMarten Szibor0Marten Szibor1Marie Mühlon2Torsten Doenst3Jaakko L. O. Pohjoismäki4Department of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich-Schiller University of Jena, Jena, GermanyBioMediTech and Tampere University Hospital, Faculty of Medicine and Health Technology, Tampere University, Tampere, FinlandDepartment of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich-Schiller University of Jena, Jena, GermanyDepartment of Cardiothoracic Surgery, Center for Sepsis Control and Care (CSCC), Jena University Hospital, Friedrich-Schiller University of Jena, Jena, GermanyDepartment of Environmental and Biological Sciences, University of Eastern Finland, Joensuu, FinlandCardiomyocytes depend on mitochondrial oxidative phosphorylation (OXPHOS) for energy metabolism, which is facilitated by the mitochondrial electron transfer system (ETS). In a series of thermogenic redox reactions, electrons are shuttled through the ETS to oxygen as the final electron acceptor. This electron transfer is coupled to proton translocation across the inner mitochondrial membrane, which itself is the main driving force for ATP production. Oxygen availability is thus a prerequisite for ATP production and consequently contractility. Notably, cardiomyocytes are exceptionally large cells and densely packed with contractile structures, which constrains intracellular oxygen distribution. Moreover, oxygen must pass through layers of actively respiring mitochondria to reach the ones located in the innermost contractile compartment. Indeed, uneven oxygen distribution was observed in cardiomyocytes, suggesting that local ATP supply may also vary according to oxygen availability. Here, we discuss how spatial adjustment of bioenergetics to intracellular oxygen fluctuations may underlie cardiac contractile adaptation and how this adaptation may pose a risk for the development of contractile failure.https://www.frontiersin.org/articles/10.3389/fmmed.2023.1305960/fullmitochondriaspatial bioenergeticsmammalian heartcontractilityheart failure |
| spellingShingle | Marten Szibor Marten Szibor Marie Mühlon Torsten Doenst Jaakko L. O. Pohjoismäki Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure Frontiers in Molecular Medicine mitochondria spatial bioenergetics mammalian heart contractility heart failure |
| title | Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure |
| title_full | Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure |
| title_fullStr | Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure |
| title_full_unstemmed | Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure |
| title_short | Spatial adjustment of bioenergetics, a possible determinant of contractile adaptation and development of contractile failure |
| title_sort | spatial adjustment of bioenergetics a possible determinant of contractile adaptation and development of contractile failure |
| topic | mitochondria spatial bioenergetics mammalian heart contractility heart failure |
| url | https://www.frontiersin.org/articles/10.3389/fmmed.2023.1305960/full |
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