Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming

Sodium-glucose cotransporter 2 inhibitors attenuate vascular calcification by suppressing endoplasmic reticulum protein thioredoxin domain containing 5 dependent osteogenic reprogramming

Aims: Vascular calcification is strongly linked to the development of major adverse cardiovascular events, but effective treatments are lacking. Sodium-glucose cotransporter 2 (SGLT2) inhibitors are an emerging category of oral hypoglycemic drugs that have displayed marked effects on metabolic and c...

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Bibliographic Details
Main Authors: Shaofa Wu, Xiaolin Luo, Yang Chen, Zelan Wang, Xi Liu, Ning Sun, Junyong Zhao, Wenjian Luo, Jiawen Zhang, Xiaoyong Tong, Lan Huang, Chuan Liu, Zhexue Qin
Format: Article
Language:English
Published: Elsevier 2024-07-01
Series:Redox Biology
Subjects:
Sodium-glucose cotransporter 2 inhibitors
Vascular calcification
Thioredoxin domain containing 5
Runx2
Endoplasmic reticulum stress
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231724001617

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http://www.sciencedirect.com/science/article/pii/S2213231724001617

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