Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis

Inhibition of PGE2 in Subchondral Bone Attenuates Osteoarthritis

Aberrant subchondral bone architecture is a crucial driver of the pathological progression of osteoarthritis, coupled with increased sensory innervation. The sensory PGE2/EP4 pathway is involved in the regulation of bone mass accrual by the induction of differentiation of mesenchymal stromal cells....

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Bibliographic Details
Main Authors: Qi Sun, Yuanzhen Zhang, Yilan Ding, Wenqing Xie, Hengzhen Li, Shaohua Li, Yusheng Li, Ming Cai
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
subchondral bone
PGE2
osteoarthritis
bone remodeling
sensory nerve
COX2
Online Access:https://www.mdpi.com/2073-4409/11/17/2760

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https://www.mdpi.com/2073-4409/11/17/2760

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