Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus

Etonogestrel Administration Reduces the Expression of PHOX2B and Its Target Genes in the Solitary Tract Nucleus

Heterozygous mutations of the transcription factor <i>PHOX2B</i> are responsible for Congenital Central Hypoventilation Syndrome, a neurological disorder characterized by inadequate respiratory response to hypercapnia and life-threatening hypoventilation during sleep. Although no cure is...

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Bibliographic Details
Main Authors: Silvia Cardani, Tara A. Janes, Jasmeen K. Saini, Simona Di Lascio, Roberta Benfante, Diego Fornasari, Silvia Pagliardini
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:International Journal of Molecular Sciences
Subjects:
congenital central hypoventilation syndrome
chemoreflex response
breathing
transcription
autonomic nervous system
progesterone
Online Access:https://www.mdpi.com/1422-0067/23/9/4816

Internet

https://www.mdpi.com/1422-0067/23/9/4816

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