Engineering of a Bispecific Nanofitin with Immune Checkpoint Inhibitory Activity Conditioned by the Cross-Arm Binding to EGFR and PDL1

Engineering of a Bispecific Nanofitin with Immune Checkpoint Inhibitory Activity Conditioned by the Cross-Arm Binding to EGFR and PDL1

Re-education of the tumor microenvironment with immune checkpoint inhibitors (ICI) has provided the most significant advancement in cancer management, with impressive efficacy and durable response reported. However, low response rates and a high frequency of immune-related adverse events (irAEs) rem...

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Bibliographic Details
Main Authors: Perrine Jacquot, Javier Muñoz-Garcia, Maurine Fleury, Denis Cochonneau, Rémi Gaussin, Elise Enouf, Caroline Roze, Emilie Ollivier, Mathieu Cinier, Dominique Heymann
Format: Article
Language:English
Published: MDPI AG 2023-03-01
Series:Biomolecules
Subjects:
epidermal growth factor receptor (EGFR)
programmed cell death ligand 1 (PDL1)
bispecific Nanofitin
tumor specific
immune checkpoint inhibitor (ICI)
Online Access:https://www.mdpi.com/2218-273X/13/4/636

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https://www.mdpi.com/2218-273X/13/4/636

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