Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets
This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegratin...
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| Format: | Article |
| Language: | English |
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Elsevier
2019-11-01
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| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844019364242 |
| _version_ | 1818299517527654400 |
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| author | Takashi Tomita Akiko Yamaguchi Naoe Nishimura Hidekazu Goto Kenji Sumiya Ryo Arakawa Tadashi Yoshida Hidehisa Tachiki Yukinao Kohda Kenzo Kudo |
| author_facet | Takashi Tomita Akiko Yamaguchi Naoe Nishimura Hidekazu Goto Kenji Sumiya Ryo Arakawa Tadashi Yoshida Hidehisa Tachiki Yukinao Kohda Kenzo Kudo |
| author_sort | Takashi Tomita |
| collection | DOAJ |
| description | This study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegrating tablets immersed in food thickener was prolonged, whereas that of the tablets immersed in jelly wafer was shortened. The dissolution behavior of non-immersed levofloxacin orally disintegrating tablets was not similar to that of tablets immersed in food thickener, but was similar to that of tablets immersed in jelly wafer. The time to reach the maximum systemic levofloxacin concentration was the same for non-immersed orally disintegrating tablets and tablets immersed in food thickener and jelly wafer. Moreover, there was no significant difference in the maximum concentration after administration between non-immersed orally disintegrating tablets and tablets immersed in food thickener or jelly wafer. These findings suggest that drugs with a high bioavailability, such as levofloxacin, enter the systemic circulation even when administered with a food thickener or jelly wafer. |
| first_indexed | 2024-12-13T04:52:29Z |
| format | Article |
| id | doaj.art-7ae45125e6bb40bc9fd362adbec19ec8 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-13T04:52:29Z |
| publishDate | 2019-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-7ae45125e6bb40bc9fd362adbec19ec82022-12-21T23:58:58ZengElsevierHeliyon2405-84402019-11-01511e02764Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tabletsTakashi Tomita0Akiko Yamaguchi1Naoe Nishimura2Hidekazu Goto3Kenji Sumiya4Ryo Arakawa5Tadashi Yoshida6Hidehisa Tachiki7Yukinao Kohda8Kenzo Kudo9Department of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Iwate, 028-3694, Japan; Department of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan; Corresponding author.TOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, JapanTOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, JapanDepartment of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, JapanFaculty of Pharmacy, Iwaki Meisei University, 5-5-1 Chuodai Iino, Iwaki, Fukushima, 970-8551, JapanThe Nisshin OilliO Group, Ltd., Central Research Laboratory, 1 Shinmori-cho, Isogo-ku, Yokohama 235-8558, JapanDepartment of Internal Medicine, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515 JapanTOWA Pharmaceutical Co., Ltd., Kyoto Analytical Science Center, Kyoto Research Park KISTIC #202, 134, Chudoji Minami-machi, Shimogyo-ku, Kyoto, Kyoto, 600-8813, JapanDepartment of Pharmacy, Hospital Bando, 411 Kutsukake, Bando, Ibaraki, 306-0515, Japan; Faculty of Health Sciences, Tsukuba International University, 6-20-1 Manabe, Tsuchiura, Ibaraki, 300-0051, JapanDepartment of Clinical Pharmaceutics and Pharmacy Practice, School of Pharmacy, Iwate Medical University, 2-1-1, Nishitokuta, Yahabacho, Shiwagun, Iwate, 028-3694, JapanThis study was designed to determine the effects of a food thickener and deglutition aid jelly for oral administration, jelly wafer, on the pharmacokinetics of levofloxacin orally disintegrating tablets. With an increase in immersion time, the disintegration time of levofloxacin orally disintegrating tablets immersed in food thickener was prolonged, whereas that of the tablets immersed in jelly wafer was shortened. The dissolution behavior of non-immersed levofloxacin orally disintegrating tablets was not similar to that of tablets immersed in food thickener, but was similar to that of tablets immersed in jelly wafer. The time to reach the maximum systemic levofloxacin concentration was the same for non-immersed orally disintegrating tablets and tablets immersed in food thickener and jelly wafer. Moreover, there was no significant difference in the maximum concentration after administration between non-immersed orally disintegrating tablets and tablets immersed in food thickener or jelly wafer. These findings suggest that drugs with a high bioavailability, such as levofloxacin, enter the systemic circulation even when administered with a food thickener or jelly wafer.http://www.sciencedirect.com/science/article/pii/S2405844019364242Food technologyPharmaceutical chemistryPharmacokineticsJelly-waferLevofloxacinFood thickener |
| spellingShingle | Takashi Tomita Akiko Yamaguchi Naoe Nishimura Hidekazu Goto Kenji Sumiya Ryo Arakawa Tadashi Yoshida Hidehisa Tachiki Yukinao Kohda Kenzo Kudo Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets Heliyon Food technology Pharmaceutical chemistry Pharmacokinetics Jelly-wafer Levofloxacin Food thickener |
| title | Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| title_full | Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| title_fullStr | Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| title_full_unstemmed | Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| title_short | Effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| title_sort | effect of food thickener and jelly wafer on the pharmacokinetics of levofloxacin orally disintegrating tablets |
| topic | Food technology Pharmaceutical chemistry Pharmacokinetics Jelly-wafer Levofloxacin Food thickener |
| url | http://www.sciencedirect.com/science/article/pii/S2405844019364242 |
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