Activation of the IL-6/STAT3 pathway contributes to the pathogenesis of membranous nephropathy and is a target for Mahuang Fuzi and Shenzhuo Decoction (MFSD) to repair podocyte damage

Activation of the IL-6/STAT3 pathway contributes to the pathogenesis of membranous nephropathy and is a target for Mahuang Fuzi and Shenzhuo Decoction (MFSD) to repair podocyte damage

Background: Primary membranous nephropathy (PMN) is an autoimmune glomerular disease. IL-6 is a potential therapeutic target for PMN. Previous clinical studies have demonstrated the effectiveness of Mahuang Fuzi and Shenzhuo Decoction (MFSD) in treating membranous nephropathy. However, the mechanism...

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Bibliographic Details
Main Authors: Qihan Zhao, Haoran Dai, Hanxue Jiang, Naiqian Zhang, Fanyu Hou, Yang Zheng, Yu Gao, Wenbin Liu, Zhendong Feng, Yuehong Hu, Xinyue Tang, Hongliang Rui, Baoli Liu
Format: Article
Language:English
Published: Elsevier 2024-05-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Membranous nephropathy
Mahuang Fuzi and Shenzhuo Decoction
IL-6/STAT3
Podocyte
RNA-seq
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332224004670

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http://www.sciencedirect.com/science/article/pii/S0753332224004670

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