Genomic and clinical predictors of lacosamide response in refractory epilepsies

Genomic and clinical predictors of lacosamide response in refractory epilepsies

Abstract Objective Clinical and genetic predictors of response to antiepileptic drugs (AEDs) are largely unknown. We examined predictors of lacosamide response in a real‐world clinical setting. Methods We tested the association of clinical predictors with treatment response using regression modeling...

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Bibliographic Details
Main Authors: Sinéad B. Heavin, Mark McCormack, Stefan Wolking, Lisa Slattery, Nicole Walley, Andreja Avbersek, Jan Novy, Saurabh R. Sinha, Rod Radtke, Colin Doherty, Pauls Auce, John Craig, Michael R. Johnson, Bobby P. C. Koeleman, Roland Krause, Wolfram S. Kunz, Anthony G. Marson, Terence J. O'Brien, Josemir W. Sander, Graeme J. Sills, Hreinn Stefansson, Pasquale Striano, Federico Zara, EPIGEN Consortium, EpiPGX Consortium, Chantal Depondt, Sanjay Sisodiya, David Goldstein, Holger Lerche, Gianpiero L. Cavalleri, Norman Delanty
Format: Article
Language:English
Published: Wiley 2019-12-01
Series:Epilepsia Open
Subjects:
GWAS
lacosamide
pharmacogenomics
pharmacoresistance
refractory
Online Access:https://doi.org/10.1002/epi4.12360

Internet

https://doi.org/10.1002/epi4.12360

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