α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

α-Synuclein-mediated inhibition of ATF6 processing into COPII vesicles disrupts UPR signaling in Parkinson's disease

The unfolded protein response (UPR) monitors the folding environment within the endoplasmic reticulum (ER). Accumulation of misfolded proteins within the ER activates the UPR resulting in the execution of adaptive or non-adaptive signaling pathways. α-Synuclein (α-syn) whose accumulation and aggrega...

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Bibliographic Details
Main Authors: Joel J. Credle, Patrick A. Forcelli, Michael Delannoy, Adam W. Oaks, Eva Permaul, Deborah L. Berry, Valeriy Duka, Jonathan Wills, Anita Sidhu
Format: Article
Language:English
Published: Elsevier 2015-04-01
Series:Neurobiology of Disease
Subjects:
α-Synuclein
Unfolded protein response
ATF6
XBP1
Endoplasmic reticulum-associated degradation
COPII
Online Access:http://www.sciencedirect.com/science/article/pii/S096999611500025X

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http://www.sciencedirect.com/science/article/pii/S096999611500025X

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