Perfluorooctane sulfonate (PFOS), a novel environmental pollutant, induces liver injury in mice by activating hepatocyte ferroptosis

Perfluorooctane sulfonate (PFOS), a novel environmental pollutant, induces liver injury in mice by activating hepatocyte ferroptosis

Objective: We investigated the toxicological mechanism by which perfluorooctane sulfonate (PFOS) induces liver injury via ferroptosis. Methods: Primary mouse hepatocytes were treated with LD50 = 55 M PFOS. Their cytotoxicity was detected by CCK-8 and LDH assays, while JC-1 staining was used to ident...

תיאור מלא

מידע ביבליוגרפי
Main Authors: Yang Yang, Liuwei Xie, Yu Zhu, Yongjia Sheng, Jin Wang, Xiaohong Zhou, Wenyan Li, Chenxi Cao, Yi Yang, Chenyang Han
פורמט: Article
שפה:English
יצא לאור: Elsevier 2023-11-01
סדרה:Ecotoxicology and Environmental Safety
נושאים:
PFOS
Liver injury
Ferroptosis
Toxicology
Environmental toxin
גישה מקוונת:http://www.sciencedirect.com/science/article/pii/S0147651323011296

אינטרנט

http://www.sciencedirect.com/science/article/pii/S0147651323011296

פריטים דומים