Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival

Engineered Removal of PD-1 From the Surface of CD19 CAR-T Cells Results in Increased Activation and Diminished Survival

CAR-T cell therapy is the most advanced way to treat therapy resistant hematologic cancers, in particular B cell lymphomas and leukemias, with high efficiency. Donor T cells equipped ex vivo with chimeric receptor recognize target tumor cells and kill them using lytic granules. CAR-T cells that reco...

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Bibliographic Details
Main Authors: R. S. Kalinin, V. M. Ukrainskaya, S. P. Chumakov, A. M. Moysenovich, V. M. Tereshchuk, D. V. Volkov, D. S. Pershin, E. G. Maksimov, H. Zhang, M. A. Maschan, Y. P. Rubtsov, A. V. Stepanov
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Molecular Biosciences
Subjects:
PD-1
PD-L1
protein expression blockers
tumor microenvironment
CAR T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.745286/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.745286/full

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