β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure–Activity Relationships and Antiallodynic Activity

β-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure–Activity Relationships and Antiallodynic Activity

The protein transient receptor potential melastatin type 8 (TRPM8), a non-selective, calcium (Ca<sup>2+</sup>)-permeable ion channel is implicated in several pathological conditions, including neuropathic pain states. In our previous research endeavors, we have identified β-lactam deriva...

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Bibliographic Details
Main Authors: Cristina Martín-Escura, M. Ángeles Bonache, Jessy A. Medina, Alicia Medina-Peris, Jorge De Andrés-López, Sara González-Rodríguez, Sara Kerselaers, Gregorio Fernández-Ballester, Thomas Voets, Antonio Ferrer-Montiel, Asia Fernández-Carvajal, Rosario González-Muñiz
Format: Article
Language:English
Published: MDPI AG 2023-10-01
Series:International Journal of Molecular Sciences
Subjects:
TRPM8 channel
β-lactams
antagonists
docking
antinociceptive activity
Online Access:https://www.mdpi.com/1422-0067/24/19/14894

Internet

https://www.mdpi.com/1422-0067/24/19/14894

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