Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility

Development of Combretastatin A-4 Analogues as Potential Anticancer Agents with Improved Aqueous Solubility

Combretastatin A-4 (CA-4) is a potent tubulin polymerisation inhibitor. However, the clinical application of CA-4 is limited owing to its low aqueous solubility and the easy conversion of the olefin double bond from the more active <i>cis-</i> to the less active <i>trans</i>-...

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Bibliographic Details
Main Authors: Zhi-Hao Chen, Run-Mei Xu, Guang-Hao Zheng, Ye-Zhi Jin, Yuan Li, Xin-Yuan Chen, Yu-Shun Tian
Format: Article
Language:English
Published: MDPI AG 2023-02-01
Series:Molecules
Subjects:
CA-4 analogs
cyano
structural development
anticancer
aqueous solubility
Online Access:https://www.mdpi.com/1420-3049/28/4/1717

Internet

https://www.mdpi.com/1420-3049/28/4/1717

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