Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Immunostimulatory gene therapy targeting CD40, 4-1BB and IL-2R activates DCs and stimulates antigen-specific T-cell and NK-cell responses in melanoma models

Abstract Background The activation of dendritic cells (DCs) is pivotal for generating antigen-specific T-cell responses to eradicate tumor cells. Hence, immunotherapies targeting this interplay are especially intriguing. Moreover, it is of interest to modulate the tumor microenvironment (TME), as th...

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Bibliographic Details
Main Authors: Jessica Wenthe, Emma Eriksson, Ann-Charlotte Hellström, Rafael Moreno, Gustav Ullenhag, Ramon Alemany, Tanja Lövgren, Angelica Loskog
Format: Article
Language:English
Published: BMC 2023-07-01
Series:Journal of Translational Medicine
Subjects:
Oncolytic adenovirus
Immunotherapy
Dendritic cells
T cells
IL-2
CD40L
Online Access:https://doi.org/10.1186/s12967-023-04374-2

Internet

https://doi.org/10.1186/s12967-023-04374-2

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