The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia

The impact of SLCO1B1 rs4149056 on LDL-C target achievement after lipid lowering therapy optimization in men and women with familial hypercholesterolemia

Background and aimsFH women are less likely to receive intensive statin treatment and to obtain a 50% reduction of LDL-C from baseline compared to men with FH. SLCO1B1 rs4149056 might influence statin therapy compliance and thus LDL-C target achievement. Our aim was to evaluate the impact of SLCO1B1...

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Main Authors: Giosiana Bosco, Francesco Di Giacomo Barbagallo, Maurizio Di Marco, Nicoletta Miano, Sabrina Scilletta, Salvatore Spampinato, Alessio Vitale, Federica Di Bella, Maria Montalbano, Stefania Di Mauro, Agnese Filippello, Alessandra Scamporrino, Agostino Milluzzo, Antonino Di Pino, Lucia Frittitta, Francesco Purrello, Salvatore Piro, Roberto Scicali
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Endocrinology
Subjects:
familial hypercholesterolemia
LDL-C target
lipid lowering therapy
SLCO1B1 rs4149056
cardiovascular risk
Online Access:https://www.frontiersin.org/articles/10.3389/fendo.2024.1346152/full

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https://www.frontiersin.org/articles/10.3389/fendo.2024.1346152/full

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