Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes

Ex vivo modulation of intact tumor fragments with anti-PD-1 and anti-CTLA-4 influences the expansion and specificity of tumor-infiltrating lymphocytes

Checkpoint inhibition (CPI) therapy and adoptive cell therapy with autologous tumor-infiltrating lymphocytes (TIL-based ACT) are the two most effective immunotherapies for the treatment of metastatic melanoma. While CPI has been the dominating therapy in the past decade, TIL-based ACT is beneficial...

Full description

Bibliographic Details
Main Authors: Thomas Morgan Hulen, Christina Friese, Nikolaj Pagh Kristensen, Joachim Stoltenborg Granhøj, Troels Holz Borch, Marlies J. W. Peeters, Marco Donia, Mads Hald Andersen, Sine Reker Hadrup, Inge Marie Svane, Özcan Met
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-06-01
Series:Frontiers in Immunology
Subjects:
tumor-infiltrating lymphocyte (TIL)
checkpoint inhibition
metastatic melanoma
cancer immunotherapy
tumor microenevironment
adoptive cell immunotherapy
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180997/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2023.1180997/full

Similar Items