High-Affinity Neutralizing DNA Aptamers against SARS-CoV-2 Spike Protein Variants

High-Affinity Neutralizing DNA Aptamers against SARS-CoV-2 Spike Protein Variants

The continuous emergence of new variants of concern for SARS-CoV-2 has created a challenge for existing therapies. To address this, we developed a series of single-stranded DNA aptamers that not only bind specifically to the trimer S protein of SARS-CoV-2 but also block the interaction between the t...

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Bibliographic Details
Main Authors: Mohamad Ammar Ayass, Natalya Griko, Victor Pashkov, Trivendra Tripathi, Wanying Cao, Nazanin Javan, Jun Dai, Jin Zhang, Kevin Zhu, Lina Abi-Mosleh
Format: Article
Language:English
Published: MDPI AG 2023-04-01
Series:COVID
Subjects:
DNA apatmer
COVID-19
SARS-CoV-2 virus
spike protein
SARS-CoV-2 variants
innovative therapy
Online Access:https://www.mdpi.com/2673-8112/3/4/38

Internet

https://www.mdpi.com/2673-8112/3/4/38

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