STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

STING agonism enhances anti-tumor immune responses and therapeutic efficacy of PARP inhibition in BRCA-associated breast cancer

Abstract Poly (ADP-ribose) polymerase (PARP) inhibitors exert their efficacy via synthetic lethal effects and by inducing cGAS/STING-mediated immune responses. We demonstrate that compared to monotherapies, combined PARP inhibition and STING agonism results in increased STING pathway activation, gre...

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Bibliographic Details
Main Authors: Constantia Pantelidou, Heta Jadhav, Aditi Kothari, Renyan Liu, Gerburg M. Wulf, Jennifer L. Guerriero, Geoffrey I. Shapiro
Format: Article
Language:English
Published: Nature Portfolio 2022-09-01
Series:npj Breast Cancer
Online Access:https://doi.org/10.1038/s41523-022-00471-5

Internet

https://doi.org/10.1038/s41523-022-00471-5

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